This study used Ken Wilber’s integral theory to discuss the possibility of mental revolution necessary in the era of the 4th Industrial Revolution through Seon Buddhism’s theory of transformation of consciousness. This study was discussed from a meditative perspective in four ways. First, I examined that the perspective of the 4th Industrial Revolution presented by Klaus Schwab emphasizes the need for spiritual and cultural values for human coexistence from the existing technology and material-centered perspective. Second, it was discussed that research on the 4th Industrial Revolution needed to be conducted in an integrated manner, and this possibility was examined through Ken Wilber’s integrated approach, IOS (Integral Operating System). Third, among the ‘four quadrants of the integrated 4th industrial revolution’, ‘I [self-transcendence(Seon Buddhism)]’ in the left-top quadrant is again categorized into ‘I(Buddha nature)’, ‘We(no difference between oneself and others)’, ‘It [body (Interaction)]’, and ‘Them (hyper-connected society)’. Fourth, this study discussed from the perspective of Seon Buddhism’s theory of transformation of consciousness, focusing on ‘I (Buddha nature)’ among the ‘four quadrants in integrated self-transcendence (Seon Buddhism)’.